Extraordinary scientific advances are giving us new tools to tackle challenging health problems. Increasingly these innovations spring from the merging of engineering and the physical and biological sciences to develop new technologies that will improve health. Significant growth in this field is mirrored by emergent opportunities for funding and partnership between academia and industry. Across several disciplines, ßÙßÇÂþ» has built unique expertise in biosensors and microfluidics. Development of biosensors that monitor other adverse consequences of drug administration (e.g., contraindications, toxicity), biomarkers of disease state(s), or companion diagnostic systems to monitor responses and improve strategies for drug treatment are in great demand. Extant and burgeoning strengths in engineering, mathematics and computer science in collaboration with life and physical sciences will catalyze productive advances in modeling of physiological systems (e.g., animal models) that will facilitate the design and implementation of these technologies.